产品货号：
Z11943
中文名称：
Beta Amyloid APP抗体
英文名称：
Anti-Beta Amyloid APP Antibody
产品规格：
100μg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Beta Amyloid APP Antibody |
| 指标别名 | ABETA;ABPP;amyloid beta 1-42;Amyloid beta A4 protein;amyloid P;amyloid precursor protein;Amyloid-beta precursor protein;Amyloid-beta protein 40;Amyloid-beta protein 42;APP;APPI;Aβ1-42;beta Amyloid |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse |
| 应用范围 | ELISA,IF,IHC,WB |
| 基因名称 | APP |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | This antibody was affinity purified from whole rabbit serum prepared by repeated immunizations with a synthetic peptide corresponding to an extracellular region of human beta amyloid conjugated to KLH using maleimide. |
| 计算分子量 | 87kDa |
| 成分 | 0.02M Potassium Phosphate,0.15M Sodium Chloride,pH7.2,0.01% (w/v) Sodium Azide |
| 纯化方式 | This affinity purified antibody is directed against extracellular region of beta amyloid and is useful in determining its presence in various assays.Polyclonal anti-beta amyloid detects human and mouse beta amyloid.Blast analysis of the sequence of the immunogen shows 100% identity with Human,Guinea Pig,Pig,Cyno Monkey,Dog,Polar Bear,Rabbit,Chimp,Squirrel monkey,and Sheep.Cross-reactivity with beta amyloid from other species is likely but has not been determined. |
| 浓度 | 1.1mg/mL by UV absorbance at 280nm |
| 产品形态 | 溶液 |
| 保存条件 | Store vial at -20℃ prior to opening.Aliquot contents and freeze at -20℃ or below for extended storage.Avoid cycles of freezing and thawing.Centrifuge product if not completely clear after standing at room temperature.This product is stable for several weeks at 4℃ as an undiluted liquid.Dilute only prior to immediate use.Expiration date is one (1) year from date of opening. |
| 背景资料 | Beta amyloid,often abbreviated as A-beta,is a protein that builds up in the brains of persons with Alzheimer's disease,collecting in clumps called plaques or senile plaques.While some researchers question whether beta amyloid is the cause of the dementia,most agree that it is involved in the disruption of thinking that is a hallmark of the disease.In some cases of familial Alzheimer's disease,mutations in genes for the proteins called the presenilins lead to increased production of amyloid.Researchers have been looking at how presenilin-1 in particular contributes to the excess buildup of beta amyloid.Presenilin-1 apparently acts to increase the activity of gamma-secretase,an enzyme that changes a normal protein (amyloid precursor protein or APP) into beta amyloid itself.Furthermore,presenilin-1 might be gamma-secretase.Anti-Beta Amyloid Antibody is useful for researchers interested in TLR signaling and Alzheimer's research. |
| Uniprot ID | P05067 |
| 基因名全称 | Amyloid beta A4 protein |
| 推荐稀释比 | ELISA:1:10,000 - 1:30,000 IHC:1:50～1:200 IF Microscopy:1:50～1:200 WB:1:1,000-1:5000 |
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